The legalization of medical marijuana (CBD hemp seed oil) has become a hot topic of discussion in many countries around the world.
In addition to the fiber being used as rope or fabric, the seeds can also be used to extract oil and have a wide range of medical value.
Since the discovery of cannabidiol and tetrahydrocannabinol (THC), the main components of cannabis, a variety of medical uses have slowly emerged.
What is CBD oil/CBD hemp seed oil?
The main component of CBD oil: Cannabidiol, one of the nearly 100 active ingredients in the cannabis plant, does not affect psychological states, unlike the most prestigious tetrahydrocannabinol (THC).
It also has anti-inflammatory, anti-convulsant, anti-oxidant, anti-emetic, anti-anxiety, and anti-psychotic benefits, and is gaining attention for its potential therapeutic effects on some refractory diseases (e.g., intractable epilepsy, Parkinson’s disease, anxiety disorders, etc.).
What are the recommended proven benefits?
Benefits for Epilepsy
Epilepsy represents a range of brain disorders of varying degrees, triggered by disturbances in neuronal electrical activity, with seizures that involve strange behaviors, emotions, and sensations, and may be accompanied by seizures, muscle spasms, and loss of consciousness.
The main causative factors of epilepsy include injury or inflammation of the brain or meningeal areas, stroke and tumors, which are called symptomatic epilepsy, but in most cases there is often no clear cause.
In a 6-month study of 74 people under the age of 18 with refractory epilepsy, the use of medical-grade cannabis seed oil rich in cannabidiol (CBD) was shown to reduce seizure frequency and to show varying degrees of improvement in behavior, alertness, language, communication, motor skills, and sleep after treatment.
Conclusion: CBD hemp seed oil may be effective in refractory epilepsy, but due to the size and methodology of the study, more large studies are needed to further confirm this.
Improve Parkinson’s Disease
Parkinson’s disease is a disease caused by abnormalities in the basal ganglia of the extrapyramidal system, with a prevalence of 2% over the age of 60 and a male to female ratio of about 3:2.
The main features of Parkinson’s disease are loss of dopaminergic function and decreased motor function (including resting tremor, bradykinesia, and muscle stiffness), and the causative factors are related to exposure to pesticides and other toxic substances, family history, and oophorectomy, but aging is the most important factor.
A double-blind controlled study of 21 Parkinson’s disease patients without dementia or other psychiatric conditions showed an improvement in the quality of life measures with cannabidiol (CBD) compared to placebo (but no significant difference in motor symptoms or neuroprotective benefits).
Conclusion: In patients with Parkinson’s disease without psychiatric symptoms, cannabidiol (CBD) may improve their quality of life, but has no significant effect on motor function.
Schizophrenia is a complex chronic psychiatric disorder with the following main symptoms: delusions, hallucinations, disorganized speech or behavior, and impaired cognitive ability.
The main causes are related to abnormalities in neurotransmitters in the brain, including dopamine, serotonin, glutamate, and gamma-aminobutyric acid (GABA).
A systematic review (27 studies) noted that although CBD (cannabidiol) has been found in preclinical studies to improve a variety of cognitive impairments, including neurogenic (schizophrenia), neurodegenerative (Alzheimer’s disease), neuritis (meningitis, sepsis, and cerebral malaria), and neurological disorders (hepatic encephalopathy and cerebral ischemia), the effectiveness of CBD in formal clinical settings for schizophrenia remains unknown due to the lack of relevant studies to date.
Conclusion: Due to the small number of studies, there is still no clear conclusion on whether CBD (cannabidiol) is beneficial for schizophrenia, and more empirical observations are needed.
CBD and cardiovascular function
Cardiovascular disease is currently one of the most burdensome diseases in the health care system, and about 90% of common myocardial infarctions are associated with population attributable risks, including cholesterol ratios, smoking, diabetes, hypertension, abdominal obesity, psycho-emotional factors, fruit/vegetable intake, physical activity, and alcohol consumption.
By 2020, cardiovascular disease is expected to surpass infectious diseases as the leading cause of human disability and death worldwide, increasing from 25% in the 1990s to 40% in 2020.
A systematic review of the literature and a meta-analysis of 22 studies showed that CBD use had no significant effect on blood pressure and heart rate improvement in a controlled state.
However, under stress conditions, it had a hypotensive and heart rate lowering effect and was found to increase cerebral blood flow in an animal model of Ischemia reperfusion injury.
Conclusion: Cannabidiol has been found to have a positive effect on cardiovascular function in animal models, but the relevant human evidence is still insufficient.
Does CBD hemp seed oil have side effects?
The limited research available so far has found that cannabidiol/CBD is a potentially safe (POSSIBLY SAFE) substance for humans.
No adverse tolerances or toxic reactions have been found at appropriate doses but reported side effects include fatigue, diarrhea, dry mouth, low blood pressure, mild headache, drowsiness, and appetite/weight changes.
Safety precautions (contraindications to the use of CBD products)
Do not use if you are pregnant, nursing mothers, or have poor liver or kidney function (due to unknown safety concerns).
Do not combine with medication as it may inhibit cytochrome P450, an enzyme in the liver associated with metabolism of medication, which may affect the action of the medication and pose an unknown risk.
High doses may cause worsening of tremor and muscle movement symptoms in patients with Parkinson’s disease.